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OCTN2 Antibody / SLC22A5

CAT: 0800-R31295Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31295Size:100 µg
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Description
Solute carrier family 22 (organic cation/carnitine transporter) member 5, also called SLC22A5 or OCTN2 is a membrane transport protein associated with primary carnitine deficiency. This gene is mapped to 5q31.1. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q9Z0E8
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of mouse SLC22A5/OCTN2 (KQWQIQSQTRMQKDGEE) was used as the immunogen for this OCTN2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the OCTN2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This OCTN2 antibody is available for research use only.
Storage Conditions
After reconstitution, the OCTN2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the OCTN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of OCTN2 antibody and Lane 1: rat kidney; 2: (r) skeletal muscles; 3: mouse liver; 4: (m) HEPA; 5: (m) NIH3T3 cell lysate. Expected/observed size ~63KD

UniProtKB · Q9Z0E8

Organic cation/carnitine transporter 2

S22A5_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q9Z0E8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Slc22a5
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Ligand

ATP-bindingNucleotide-bindingSodium

Cellular component

Cell membraneMembrane

Disease

Disease variant

PTM

GlycoproteinPhosphoprotein

Biological process

Ion transportSodium transportSymportTransport

Technical term

Reference proteome

Domain

TransmembraneTransmembrane helix

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Alternative Products

CatalogName
MBS2401502-01Anti-SLC22A5/OCTN2 Antibody
A01527-1Anti-OCTN2/SLC22A5 Antibody
NBP2-83304-0.1mLRabbit Polyclonal OCTN2/SLC22A5 Antibody
APR10020GPolyclonal SLC22A5 / OCTN2 Antibody (aa282-331)
FAB11004AMouse Monoclonal OCTN2/SLC22A5 Antibody (893753) [Allophycocyanin]
FAB11004BMouse Monoclonal OCTN2/SLC22A5 Antibody (893753) [Biotin]
FAB11004CMouse Monoclonal OCTN2/SLC22A5 Antibody (893753) [PerCP]
FAB11004PMouse Monoclonal OCTN2/SLC22A5 Antibody (893753) [PE]
FAB11004FMouse Monoclonal OCTN2/SLC22A5 Antibody (893753) [FITC]
FAB11004HMouse Monoclonal OCTN2/SLC22A5 Antibody (893753) [HRP]

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