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TLR6 Antibody

CAT: 0800-F44377-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F44377-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TLR6 participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Cooperates with TLR2 for the cellular activation. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. [UniProt]
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:50-1:100, Western blot: 1:1000
UniProt
Q9EPW9
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 1-30 from the mouse protein was used as the immunogen for this TLR6 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TLR6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TLR6 antibody is available for research use only.
Storage Conditions
Aliquot the TLR6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TLR6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
TLR6 antibody western blot analysis in MCF-7 lysate

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