SARS-CoV-2 Spike RBD Beta Variant

• Description:

  SARS-CoV-2 Spike RBD Beta Variant_x000D_ Catalog number: B2010499_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 100 ug_x000D_ Molecular Weight or Concentration: 27 kDa_x000D_ Supplied as: Lyophilized Powder_x000D_ Applications: molecular component of many serological and antigenic assays for SARS-CoV-2 and its variants_x000D_ Storage: -20„ƒ_x000D_ Keywords: Beta Variant Spike, B.1.351 Spike RBD, Beta RBD_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ Download SARS-CoV-2 Brochure_x000D_ _x000D_ References:_x000D_ 1: Rattanapisit K, Bulaon CJI, Khorattanakulchai N, Shanmugaraj B, Wangkanont K,_x000D_ Phoolcharoen W. Plant-produced SARS-CoV-2 receptor binding domain (RBD) variants_x000D_ showed differential binding efficiency with anti-spike specific monoclonal_x000D_ antibodies. PLoS One. 2021 Aug 11;16(8):e0253574._x000D_ _x000D_ 2: Kim S, Liu Y, Lei Z, Dicker J, Cao Y, Zhang XF, Im W. Differential_x000D_ Interactions Between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern._x000D_ bioRxiv [Preprint]. 2021 Jul 26:2021.07.23.453598._x000D_ _x000D_ 3: Peters MH, Bastidas O, Kokron DS, Henze CE. Transformations, Lineage_x000D_ Comparisons, and Analysis of Down to Up Protomer States of Variants of the SARS-_x000D_ CoV-2 Prefusion Spike Protein Including the UK Variant B.1.1.7. bioRxiv_x000D_ [Preprint]. 2021 Apr 2:2021.02.09.430519._x000D_ _x000D_ 4: Trigueiro-Louro J, Correia V, Figueiredo-Nunes I, Gíria M, Rebelo-de-Andrade_x000D_ H. Unlocking COVID therapeutic targets: A structure-based rationale against_x000D_ SARS-CoV-2, SARS-CoV and MERS-CoV Spike. Comput Struct Biotechnol J. 2020 Jul_x000D_ 31;18:2117-2131._x000D_ _x000D_ 5: Jawad B, Adhikari P, Podgornik R, Ching WY. Key Interacting Residues between_x000D_ RBD of SARS-CoV-2 and ACE2 Receptor: Combination of Molecular Dynamics_x000D_ Simulation and Density Functional Calculation. J Chem Inf Model. 2021 Aug_x000D_ 24:acs.jcim.1c00560._x000D_ _x000D_ 6: Zahradník J, Marciano S, Shemesh M, Zoler E, Harari D, Chiaravalli J, Meyer_x000D_ B, Rudich Y, Li C, Marton I, Dym O, Elad N, Lewis MG, Andersen H, Gagne M, Seder_x000D_ RA, Douek DC, Schreiber G. SARS-CoV-2 variant prediction and antiviral drug_x000D_ design are enabled by RBD in vitro evolution. Nat Microbiol. 2021_x000D_ Sep;6(9):1188-1198._x000D_ _x000D_ 7: Ou J, Zhou Z, Dai R, Zhang J, Zhao S, Wu X, Lan W, Ren Y, Cui L, Lan Q, Lu L,_x000D_ Seto D, Chodosh J, Wu J, Zhang G, Zhang Q. V367F Mutation in SARS-CoV-2 Spike_x000D_ RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity_x000D_ through Increased Human ACE2 Receptor Binding Affinity. J Virol. 2021 Jul_x000D_ 26;95(16):e0061721._x000D_ _x000D_ 8: Mohammadi M, Shayestehpour M, Mirzaei H. The impact of spike mutated variants_x000D_ of SARS-CoV2 [Alpha, Beta, Gamma, Delta, and Lambda] on the efficacy of subunit_x000D_ recombinant vaccines. Braz J Infect Dis. 2021 Aug 17;25(4):101606._x000D_ _x000D_ 9: Barton MI, MacGowan SA, Kutuzov MA, Dushek O, Barton GJ, van der Merwe PA._x000D_ Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand the human_x000D_ ACE2 receptor on binding affinity and kinetics. Elife. 2021 Aug 26;10:e70658._x000D_ 10: Tsai MS, Yang YH, Lin YS, Chang GH, Hsu CM, Yeh RA, Shu LH, Cheng YC, Liu_x000D_ HT, Wu YH, Wu YH, Shen RC, Wu CY. GB-2 blocking the interaction between ACE2 and_x000D_ wild type and mutation of spike protein of SARS-CoV-2. Biomed Pharmacother. 2021_x000D_ Aug 5;142:112011. _x000D_ _x000D_ Products Related to SARS-CoV-2 Spike RBD Beta Variant : SARS-CoV-2

• Short Description:

  Catalog Number: B2010499 (100 ug)_x000D_ SARS-CoV-2 Spike RBD Beta Variant is a highly pure recombinant SARS-CoV-2 RBD from the Beta Variant lineage (B.1.351, with K417N, E484K, N501Y mutations) expressed in HEK293 cells. This product has been used as molecular component of many serological and antigenic assays for SARS-CoV-2 and its variants. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5