SARS-CoV-2 Spike RBD Alpha Variant

• Description:

  SARS-CoV-2 Spike RBD Alpha Variant_x000D_ Catalog number: B2010498_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 100 ug_x000D_ Molecular Weight or Concentration: 27 kDa_x000D_ Supplied as: Lyophilized Powder_x000D_ Applications: molecular component of many serological and antigenic assays for SARS-CoV-2 and its variants_x000D_ Storage: -20„ƒ_x000D_ Keywords: Alpha Variant Spike, B.1.1.7 Spike RBD, Alpha RBD_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ Download SARS-CoV-2 Brochure_x000D_ _x000D_ References:_x000D_ 1: Planas D, Veyer D, Baidaliuk A, Staropoli I, Guivel-Benhassine F, Rajah MM,_x000D_ Planchais C, Porrot F, Robillard N, Puech J, Prot M, Gallais F, Gantner P, Velay_x000D_ A, Le Guen J, Kassis-Chikhani N, Edriss D, Belec L, Seve A, Courtellemont L,_x000D_ Péré H, Hocqueloux L, Fafi-Kremer S, Prazuck T, Mouquet H, Bruel T, Simon-_x000D_ Lorière E, Rey FA, Schwartz O. Reduced sensitivity of SARS-CoV-2 variant Delta_x000D_ to antibody neutralization. Nature. 2021 Aug;596(7871):276-280._x000D_ _x000D_ 2: Zahradník J, Marciano S, Shemesh M, Zoler E, Harari D, Chiaravalli J, Meyer_x000D_ B, Rudich Y, Li C, Marton I, Dym O, Elad N, Lewis MG, Andersen H, Gagne M, Seder_x000D_ RA, Douek DC, Schreiber G. SARS-CoV-2 variant prediction and antiviral drug_x000D_ design are enabled by RBD in vitro evolution. Nat Microbiol. 2021_x000D_ Sep;6(9):1188-1198_x000D_ _x000D_ 3: Kim Y, Gaudreault NN, Meekins DA, Perera KD, Bold D, Trujillo JD, Morozov I,_x000D_ McDowell CD, Chang KO, Richt JA. Effects of Spike Mutations in SARS-CoV-2_x000D_ Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and_x000D_ Neutralization. bioRxiv [Preprint]. 2021 Aug 25:2021.08.25.457627._x000D_ _x000D_ 4: Jawad B, Adhikari P, Podgornik R, Ching WY. Key Interacting Residues between_x000D_ RBD of SARS-CoV-2 and ACE2 Receptor: Combination of Molecular Dynamics_x000D_ Simulation and Density Functional Calculation. J Chem Inf Model. 2021 Aug_x000D_ 24:acs.jcim.1c00560._x000D_ _x000D_ 5: Kim S, Liu Y, Lei Z, Dicker J, Cao Y, Zhang XF, Im W. Differential_x000D_ Interactions Between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern._x000D_ bioRxiv [Preprint]. 2021 Jul 26:2021.07.23.453598._x000D_ _x000D_ 6: Rattanapisit K, Bulaon CJI, Khorattanakulchai N, Shanmugaraj B, Wangkanont K,_x000D_ Phoolcharoen W. Plant-produced SARS-CoV-2 receptor binding domain (RBD) variants_x000D_ showed differential binding efficiency with anti-spike specific monoclonal_x000D_ antibodies. PLoS One. 2021 Aug 11;16(8):e0253574._x000D_ _x000D_ 7: Lu L, Chu AW, Zhang RR, Chan WM, Ip JD, Tsoi HW, Chen LL, Cai JP, Lung DC,_x000D_ Tam AR, Yau YS, Kwan MY, To WK, Tsang OT, Lee LL, Yi H, Ip TC, Poon RW, Siu GK,_x000D_ Mok BW, Cheng VC, Chan KH, Yuen KY, Hung IF, To KK. The impact of spike N501Y_x000D_ mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent_x000D_ serum. EBioMedicine. 2021 Aug 19;71:103544._x000D_ _x000D_ 8: Barton MI, MacGowan SA, Kutuzov MA, Dushek O, Barton GJ, van der Merwe PA._x000D_ Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand the human_x000D_ ACE2 receptor on binding affinity and kinetics. Elife. 2021 Aug 26;10:e70658._x000D_ _x000D_ 9: Tian F, Tong B, Sun L, Shi S, Zheng B, Wang Z, Dong X, Zheng P. N501Y_x000D_ mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor_x000D_ ACE2. Elife. 2021 Aug 20;10:e69091._x000D_ 10: Prévost J, Richard J, Gasser R, Ding S, Fage C, Anand SP, Adam D, Vergara_x000D_ NG, Tauzin A, Benlarbi M, Gong SY, Goyette G, Privé A, Moreira S, Charest H,_x000D_ Roger M, Mothes W, Pazgier M, Brochiero E, Boivin G, Abrams CF, Schön A, Finzi_x000D_ A. Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for_x000D_ host ACE2. J Biol Chem. 2021 Aug 31:101151. _x000D_ _x000D_ Products Related to SARS-CoV-2 Spike RBD Alpha Variant : SARS-CoV-2

• Short Description:

  Catalog Number: B2010498 (100 ug)_x000D_ SARS-CoV-2 Spike RBD Alpha Variant is a highly pure recombinant SARS-CoV-2 RBD from the Alpha Variant lineage (B.1.1.7, with N501Y mutation) expressed in HEK293 cells. This product has been used as molecular component of many serological and antigenic assays for SARS-CoV-2 and its variants. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5