Biotinylated SARS-CoV-2 Spike RBD Beta Variant

• Description:

  Biotinylated SARS-CoV-2 Spike RBD Beta Variant _x000D_ Catalog number: B2010503_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 25 ug_x000D_ Molecular Weight or Concentration: 27 kDa_x000D_ Supplied as: Liquid Solution_x000D_ Applications: molecular component of many serological and antigenic assays for SARS-CoV-2 and its variants_x000D_ Storage: -20„ƒ_x000D_ Keywords: Beta Variant Spike, B.1.351 Spike RBD, Beta RBD, Biotin Beta RBD_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ Download SARS-CoV-2 Brochure_x000D_ _x000D_ References:_x000D_ 1: Aleem A, Akbar Samad AB, Slenker AK. Emerging Variants of SARS-CoV-2 And_x000D_ Novel Therapeutics Against Coronavirus (COVID-19). 2021 Jul 18. In: StatPearls_x000D_ [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan€“._x000D_ _x000D_ 2: Binette V, Côté S, Haddad M, Nguyen PT, Bélanger S, Bourgault S, Ramassamy C,_x000D_ Gaudreault R, Mousseau N. Corilagin and 1,3,6-Tri-O-galloy-β-D-glucose:_x000D_ potential inhibitors of SARS-CoV-2 variants. Phys Chem Chem Phys. 2021 Jul_x000D_ 14;23(27):14873-14888._x000D_ _x000D_ 3: Kim Y, Gaudreault NN, Meekins DA, Perera KD, Bold D, Trujillo JD, Morozov I,_x000D_ McDowell CD, Chang KO, Richt JA. Effects of Spike Mutations in SARS-CoV-2_x000D_ Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and_x000D_ Neutralization. bioRxiv [Preprint]. 2021 Aug 25:2021.08.25.457627._x000D_ _x000D_ 4: Jin D, Wei J, Sun J. Analysis of the molecular mechanism of SARS-CoV-2_x000D_ antibodies. Biochem Biophys Res Commun. 2021 Aug 20;566:45-52._x000D_ _x000D_ 5: Jette CA, Cohen AA, Gnanapragasam PNP, Muecksch F, Lee YE, Huey-Tubman KE,_x000D_ Schmidt F, Hatziioannou T, Bieniasz PD, Nussenzweig MC, West AP, Keeffe JR,_x000D_ Bjorkman PJ, Barnes CO. Broad cross-reactivity across sarbecoviruses exhibited_x000D_ by a subset of COVID-19 donor-derived neutralizing antibodies. bioRxiv_x000D_ [Preprint]. 2021 Apr 26:2021.04.23.441195._x000D_ _x000D_ 6: Malladi SK, Patel UR, Rajmani RS, Singh R, Pandey S, Kumar S, Khaleeq S, van_x000D_ Vuren PJ, Riddell S, Goldie S, Gayathri S, Chakraborty D, Kalita P, Pramanick I,_x000D_ Agarwal N, Reddy P, Girish N, Upadhyaya A, Khan MS, Kanjo K, Bhat M, Mani S,_x000D_ Bhattacharyya S, Siddiqui S, Tyagi A, Jha S, Pandey R, Tripathi S, Dutta S,_x000D_ McAuley AJ, Singanallur NB, Vasan SS, Ringe RP, Varadarajan R. Immunogenicity_x000D_ and Protective Efficacy of a Highly Thermotolerant, Trimeric SARS-CoV-2 Receptor_x000D_ Binding Domain Derivative. ACS Infect Dis. 2021 Aug 13;7(8):2546-2564._x000D_ _x000D_ 7: Chen L, Zody MC, Di Germanio C, Martinelli R, Mediavilla JR, Cunningham MH,_x000D_ Composto K, Chow KF, Kordalewska M, Corvelo A, Oschwald DM, Fennessey S,_x000D_ Zetkulic M, Dar S, Kramer Y, Mathema B, Germer S, Stone M, Simmons G, Busch MP,_x000D_ Maniatis T, Perlin DS, Kreiswirth BN. Emergence of Multiple SARS-CoV-2 Antibody_x000D_ Escape Variants in an Immunocompromised Host Undergoing Convalescent Plasma_x000D_ Treatment. mSphere. 2021 Aug 25;6(4):e0048021._x000D_ _x000D_ 8: Tian F, Tong B, Sun L, Shi S, Zheng B, Wang Z, Dong X, Zheng P. N501Y_x000D_ mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor_x000D_ ACE2. Elife. 2021 Aug 20;10:e69091._x000D_ _x000D_ 9: Makdasi E, Zvi A, Alcalay R, Noy-Porat T, Peretz E, Mechaly A, Levy Y,_x000D_ Epstein E, Chitlaru T, Tennenhouse A, Aftalion M, Gur D, Paran N, Tamir H,_x000D_ Zimhony O, Weiss S, Mandelboim M, Mendelson E, Zuckerman N, Nemet I, Kliker L,_x000D_ Yitzhaki S, Shapira SC, Israely T, Fleishman SJ, Mazor O, Rosenfeld R. The_x000D_ neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal_x000D_ antibodies is retained against viral variants. Cell Rep. 2021 Aug 21:109679._x000D_ 10: Lee YG, Kang KW, Hong W, Kim YH, Oh JT, Park DW, Ko M, Bai YF, Seo YJ, Lee_x000D_ SM, Kim H, Kang SC. Potent antiviral activity of Agrimonia pilosa, Galla rhois,_x000D_ and their components against SARS-CoV-2. Bioorg Med Chem. 2021 Sep 1;45:116329._x000D_ _x000D_ Products Related to Biotinylated SARS-CoV-2 Spike RBD Beta Variant : SARS-CoV-2

• Short Description:

  Catalog Number: B2010503 (25 ug)_x000D_ Biotinylated SARS-CoV-2 Spike RBD Beta Variant is a highly pure biotinylated recombinant SARS-CoV-2 RBD from the Beta Variant lineage (B.1.351, with K417N, E484K, N501Y mutations) expressed in HEK293 cells. This product has been used as molecular component of many serological and antigenic assays for SARS-CoV-2 and its variants. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5