AMD 3465

• UNSPSC Description:

  AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

• Target Antigen:

  CXCR; HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;GPCR/G Protein;Immunology/Inflammation

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Infection; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/amd-3465.html

• Solubility:

  H2O : ≥ 100 mg/mL

• Smiles:

  C1(CNCC2=CC=C(CN3CCNCCCNCCNCCC3)C=C2)=NC=CC=C1

• Molecular Weight:

  410.60

• References & Citations:

  [1]Hatse S, et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem Pharmacol. 2005 Sep 1;70(5):752-61.|[2]Yang L, et al. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res. 2007 Jan 15;67(2):651-8.Br J Haematol. 2022 Dec 19.|Biomed Pharmacother. 2021 Mar 24;138:111476.|J Labelled Comp Radiopharm. 2018 May 15;61(5):438-446. |Patent. US20180263995A1.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  185991-24-6