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AMD 3329 (octahydrobromide)

CAT: 0804-HY-164682Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164682Size:1 Each
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Description
AMD 3329 octahydrobromide is a potent and selective anti-HIV-1 and HIV-2 compound with activity to inhibit viral replication. AMD 3329 blocks viral invasion by binding to the chemokine receptor CXCR4. AMD 3329 exhibits EC50 values as low as 0.8 and 1.6 nM when inhibiting HIV-1 and HIV-2 replication, showing better antiviral efficacy than AMD3100. AMD 3329 significantly inhibits the binding of specific CXCR4 monoclonal antibodies and the Ca (2+) flux induced by SDF-1alpha. AMD 3329 is also able to effectively interfere with virus-induced syncytium formation, with an EC50 value of 12 nM[1].
CAS Number
170861-77-5
UNSPSC
12352005
Target
CXCR; HIV
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/amd-3329-octahydrobromide.html
Smiles
C12=CC=CC(CCNCCN(CCNCC2)CC3=CC=C(CN4CCNCCC5=CC=CC(CCNCC4)=N5)C=C3)=N1.Br.[8]
Molecular Formula
C34H58Br8N8
Molecular Weight
1218.11
References & Citations
[1]Synthesis and structure-activity relationships of phenylenebis (methylene) -linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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