AZD-3463

• Description :

  AZD-3463 (ALK/IGF1R inhibitor) is an orally active ALK/IGF1R inhibitor, with a Ki of 0.75 nM for ALK. AZD3463 induces apoptosis and autophagy in neuroblastoma cells[1][2][3].

• Product Name Alternative :

  ALK/IGF1R inhibitor

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Anaplastic lymphoma kinase (ALK) ; Apoptosis; Autophagy; IGF-1R

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/azd-3463.html

• Concentration :

  10mM

• Purity :

  99.31

• Solubility :

  DMSO : 20 mg/mL (ultrasonic)

• Smiles :

  ClC(C=NC(NC1=C(OC)C=C(N2CCC(N)CC2)C=C1)=N3)=C3C4=CNC5=C4C=CC=C5

• Molecular Formula :

  C24H25ClN6O

• Molecular Weight :

  448.95

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Yongfeng Wang, et al. Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. Sci Rep. 2016; 6: 19423.|[2]Sausan A. Moharram, et al. The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia. Blood Cancer J. 2019 Feb; 9 (2) : 5.|[3]Ozates NP, et al. Effects of rapamycin and AZD3463 combination on apoptosis, autophagy, and cell cycle for resistance control in breast cancer. Life Sci. 2021 Jan 1;264:118643.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1356962-20-3]