JMI-346

CAT: 0804-HY-147850Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-147850Size:1 Each
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Description
JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQS (3D7; IC50=13 µM) and CQR (RKL-9; IC50=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent[1].
CAS Number
[2091841-46-0]
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/jmi-346.html
Solubility
10 mM in DMSO
Smiles
N[C@@H](CC1=CC=CC=C1)C(OCC2=CN(C3=CC=C(C)C=C3)N=N2)=O
Molecular Formula
C19H20N4O2
Molecular Weight
336.39
References & Citations
[1]Uddin A, et al. Identification and structure-activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease. Bioorg Chem. 2020 Oct;103:104142.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium

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