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PPTN

CAT: 0804-HY-110322A-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110322A-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PPTN, a chemical probe, is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity[1].
CAS Number
1160271-30-6
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pptn.html
Purity
99.63
Solubility
DMSO : 12.5 mg/mL (ultrasonic; adjust pH to 7 with 1 M HCL)
Smiles
O=C(O)C1=CC(C2=CC=C(C3CCNCC3)C=C2)=C4C=CC(C5=CC=C(C(F)(F)F)C=C5)=CC4=C1
Molecular Formula
C29H24F3NO2
Molecular Weight
475.50
References & Citations
[1]Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84 (1) :41-9.|[2]Lin J, et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 2019 Dec;131:104567.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y14 Receptor
Citation 01
Cell Rep. 2025 Nov 18;44 (12) :116577.|Int Immunopharmacol. 2023 Jan:114:109507.|Clin Immunol. 2024 Jun 29:110300.|Neuropharmacology. 2025 Oct 14:110723.

Chemical Information

4-((Piperindin-4-yl)-phenyl)-(7-(4-(trifluoromethyl)-phenyl)-2-naphthoic acid
CAS Number1160271-30-6
PubChem CID42611190
IUPAC Name4-(4-piperidin-4-ylphenyl)-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
Molecular FormulaC29H24F3NO2
Molecular Weight475.5
XLogP4.7
Topological Polar Surface Area49.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count35
Formal Charge0
Complexity705
SMILES
C1CNCCC1C2=CC=C(C=C2)C3=C4C=CC(=CC4=CC(=C3)C(=O)O)C5=CC=C(C=C5)C(F)(F)F
InChI
InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
InChIKey
FOECKIWHCOYYFL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-((Piperindin-4-yl)-phenyl)-(7-(4-(trifluoromethyl)-phenyl)-2-naphthoic acid
CAS: 1160271-30-6
CID: 42611190
Formula: C29H24F3NO2
MW: 475.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight475.5
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass475.17591349
Monoisotopic Mass475.17591349
Topological Polar Surface Area49.3 Ų
Heavy Atom Count35
Formal Charge0
Complexity705
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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