A 77-01

• Description :

  A 77-01 is a potent inhibitor of transforming growth factor (TGF) -β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25 nM[1].

• CAS Number :

  [607737-87-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  TGF-β Receptor

• Type :

  Reference compound

• Related Pathways :

  TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/a-77-01.html

• Purity :

  99.92

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  CC1=CC=CC(C2=NNC=C2C3=CC=NC4=CC=CC=C34)=N1

• Molecular Formula :

  C18H14N4

• Molecular Weight :

  286.33

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96 (11) :791-800.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported