A 77-01

• Description:

  A 77-01 is a potent inhibitor of transforming growth factor (TGF) -β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25 nM[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  TGF-β Receptor

• Type:

  Reference compound

• Related Pathways:

  TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/a-77-01.html

• Purity:

  99.92

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  CC1=CC=CC(C2=NNC=C2C3=CC=NC4=CC=CC=C34)=N1

• Molecular Formula:

  C18H14N4

• Molecular Weight:

  286.33

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96 (11) :791-800.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [607737-87-1]