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A 77-01

CAT: 0804-HY-78349-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-78349-01Size:5 mg
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Description
A 77-01 is a potent inhibitor of transforming growth factor (TGF) -β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25 nM[1].
CAS Number
607737-87-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a-77-01.html
Purity
99.92
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=CC=CC(C2=NNC=C2C3=CC=NC4=CC=CC=C34)=N1
Molecular Formula
C18H14N4
Molecular Weight
286.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96 (11) :791-800.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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A3132-5.1A 77-01
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