VSP-77

• Description :

  VSP-77 is an orally active PPARγ agonist. VSP-77 selectively upregulates the expression of insulin sensitivity-related genes (Glut4 and Adiponectin) by inhibiting CDK5-mediated phosphorylation of PPARγ at Ser-273. VSP-77 significantly improves glucose tolerance, reduces fasting blood glucose and insulin levels in high-fat diet (HFD) -induced diabetic mouse models. VSP-77 can be used for the study of diabetes[1].

• UNSPSC :

  12352005

• Target :

  PPAR

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Metabolic Disease

• Smiles :

  ClC1=CC=C(C(CCCCCCC)OCC(O)=O)C=C1

• Molecular Formula :

  C16H23ClO3

• Molecular Weight :

  298.81

• References & Citations :

  [1]Jiang H, et al. Identification and structural insight of an effective PPARγ modulator with improved therapeutic index for anti-diabetic drug discovery. Chem Sci. 2020 Jan 21;11 (8) :2260-2268.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1854008-12-0]