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PolyQ aggregation inhibitor C2-8

CAT: 0804-HY-125172-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125172-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s=25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively) . It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.
CAS Number
300670-16-0
Product Name Alternative
Polyglutamine Aggregation inhibitor III
UNSPSC
12352005
Hazard Statement
H319, H413
Target
Huntingtin
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/polyq-aggregation-inhibitor-c2-8.html
Purity
99.9
Smiles
O=C(NC1=CC=C(Br)C=C1)C2=CC=CC(S(=O)(NC3=CC=C(Br)C=C3)=O)=C2
Molecular Formula
C19H14Br2N2O3S
Molecular Weight
510.20
Precautions
H319, H413
References & Citations
[1]Zhang, et al. A potent small molecule inhibits polyglutamine aggregation in Huntington’s disease neurons and suppresses neurodegeneration in vivo. Proc. Natl. Acad. Sci. USA 102 (3), 892-897 (2005) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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