Tau-aggregation-IN-1

CAT:

804-HY-146135

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UNSPSC Description:
Tau-aggregation-IN-1 (Compound D-519) is a tau441 protein aggregation inhibitor with an IC50 of 21 µM. Tau-aggregation-IN-1 is also a dopamine D2 and D3 receptor agonist[1].
Target Antigen:
Dopamine Receptor; Microtubule/Tubulin
Type:
Reference compound
Related Pathways:
Cell Cycle/DNA Damage;Cytoskeleton;GPCR/G Protein;Neuronal Signaling
Applications:
Neuroscience-Neurodegeneration
Field of Research:
Neurological Disease
Assay Protocol:
https://www.medchemexpress.com/tau-aggregation-in-1.html
Solubility:
10 mM in DMSO
Smiles:
OC(C=C1C(C=C2)=CC=C2N(CC3)CCN3CCN([C@H]4CC5=C(N=C(S5)N)CC4)CCC)=C(C=C1)O
Molecular Weight:
507.69
References & Citations:
[1]Iva Ziu, et al. The multifunctional dopamine D2/D3 receptor agonists also possess inhibitory activity against the full-length tau441 protein aggregation. Bioorg Med Chem. 2020 Sep 15;28(18):115667.
Shipping Conditions:
Room temperature
Clinical Information:
No Development Reported
CAS Number:
1619269-19-0

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