Tau-aggregation-IN-1

• Description :

  Tau-aggregation-IN-1 (Compound D-519) is a tau441 protein aggregation inhibitor with an IC50 of 21 µM. Tau-aggregation-IN-1 is also a dopamine D2 and D3 receptor agonist[1].

• UNSPSC :

  12352005

• Target :

  Dopamine Receptor; Microtubule/Tubulin

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/tau-aggregation-in-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC(C=C1C(C=C2)=CC=C2N(CC3)CCN3CCN([C@H]4CC5=C(N=C(S5)N)CC4)CCC)=C(C=C1)O

• Molecular Formula :

  C28H37N5O2S

• Molecular Weight :

  507.69

• References & Citations :

  [1]Iva Ziu, et al. The multifunctional dopamine D2/D3 receptor agonists also possess inhibitory activity against the full-length tau441 protein aggregation. Bioorg Med Chem. 2020 Sep 15;28 (18) :115667.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  D2 Receptor; D3 Receptor

• CAS Number :

  [1619269-19-0]