Tau-aggregation-IN-1

Tau-aggregation-IN-1

• CAS Number: 1619269-19-0
• UNSPSC Description: Tau-aggregation-IN-1 (Compound D-519) is a tau441 protein aggregation inhibitor with an IC50 of 21 µM. Tau-aggregation-IN-1 is also a dopamine D2 and D3 receptor agonist[1].
• Target Antigen: Dopamine Receptor; Microtubule/Tubulin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton;GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/tau-aggregation-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: OC(C=C1C(C=C2)=CC=C2N(CC3)CCN3CCN([C@H]4CC5=C(N=C(S5)N)CC4)CCC)=C(C=C1)O
• Molecular Weight: 507.69
• References & Citations: [1]Iva Ziu, et al. The multifunctional dopamine D2/D3 receptor agonists also possess inhibitory activity against the full-length tau441 protein aggregation. Bioorg Med Chem. 2020 Sep 15;28(18):115667.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported