Aβ aggregation-IN-4

• Description:

  Aβ aggregation-IN-4 can alleviate the neurotoxicity of amyloid-β protein (Aβ) and significantly reduce the level of oligomeric complexes of Aβ (Aβ-OCs) . Aβ aggregation-IN-4 does not decrease the level of amyloid-β protein (Aβ) . Aβ aggregation-IN-4 attenuates Aβ oligomerization and prevents oligomer-induced death of primary cortical neurons. Aβ aggregation-IN-4 can be used for the study of Alzheimer’s disease (AD) [1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  [H][C@]12C[C@H](CCC1=CC3=C(O2)C=C(OC3=O)C)[C@@H](CN4C=NC(N)=C5C4=NC=N5)C

• Molecular Formula:

  C21H23N5O3

• Molecular Weight:

  393.44

• References & Citations:

  [1]Maezawa I, et al. A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes. J Neurochem. 2006 Jul;98 (1) :57-67.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  603113-07-1