Aβ aggregation-IN-4

CAT: 0804-HY-177854Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-177854Size:1 Each
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Description
Aβ aggregation-IN-4 can alleviate the neurotoxicity of amyloid-β protein (Aβ) and significantly reduce the level of oligomeric complexes of Aβ (Aβ-OCs) . Aβ aggregation-IN-4 does not decrease the level of amyloid-β protein (Aβ) . Aβ aggregation-IN-4 attenuates Aβ oligomerization and prevents oligomer-induced death of primary cortical neurons. Aβ aggregation-IN-4 can be used for the study of Alzheimer’s disease (AD) [1].
CAS Number
[603113-07-1]
UNSPSC
12352005
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
[H][C@]12C[C@H](CCC1=CC3=C(O2)C=C(OC3=O)C)[C@@H](CN4C=NC(N)=C5C4=NC=N5)C
Molecular Formula
C21H23N5O3
Molecular Weight
393.44
References & Citations
[1]Maezawa I, et al. A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes. J Neurochem. 2006 Jul;98 (1) :57-67.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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