AVN-944

• UNSPSC Description:

  AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research[1][2][3].

• Target Antigen:

  Apoptosis; Arenavirus; Bcl-2 Family; Caspase; DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Apoptosis;Cell Cycle/DNA Damage

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/AVN-944.html

• Smiles:

  O=C(O[C@@H](CC#N)CC)N[C@H](C1=CC=CC(NC(NC2=CC=C(C3=CN=CO3)C(OC)=C2)=O)=C1)C

• Molecular Weight:

  477.51

• References & Citations:

  [1]Zimmermann AG, et al. Inosine-5'-monophosphate dehydrogenase: regulation of expression and role in cellular proliferation and T lymphocyte activation. Prog Nucleic Acid Res Mol Biol. 1998;61:181-209.|[2]Huang M, et al. Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar disruption. Leuk Res. 2008 Jan;32(1):131-41.|[3]Floryk D, et al. Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells. Int J Cancer. 2008 Nov 15;123(10):2294-302.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  297730-17-7