AVN-101

• Description :

  AVN-101 is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively) . AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 can be studied in such diseases as general anxiety disorders, depression, schizophrenia, Alzheimer’s disease, and multiple sclerosis[1].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Adrenergic Receptor; Histamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/avn-101.html

• Smiles :

  CC1=CC2=C(N(CCC3=CC=CC=C3)C4=C2CN(C)CC4)C=C1

• Molecular Formula :

  C21H24N2

• Molecular Weight :

  304.43

• References & Citations :

  [1]AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT2 Receptor;5-HT6 Receptor;5-HT7 Receptor

• CAS Number :

  [1025725-91-0]