AVN-101

CAT: 0804-HY-117046Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117046Size:1 Each
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Description
AVN-101 is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively) . AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 can be studied in such diseases as general anxiety disorders, depression, schizophrenia, Alzheimer’s disease, and multiple sclerosis[1].
CAS Number
[1025725-91-0]
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/avn-101.html
Smiles
CC1=CC2=C(N(CCC3=CC=CC=C3)C4=C2CN(C)CC4)C=C1
Molecular Formula
C21H24N2
Molecular Weight
304.43
References & Citations
[1]AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor;5-HT6 Receptor;5-HT7 Receptor

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Alternative Products

CatalogName
MBS5776417AVN-101
M27852-01AVN-101 hydrochloride
MBS3847014-01AVN-101 HCl
A22498-1AVN-101 HCl 1mg
A22498-200AVN-101 HCl 200mg
T71593-01AVN-101 free base
A22498-5AVN-101 HCl 5mg
A22498-10AVN-101 HCl 10mg
A22498-100AVN-101 HCl 100mg
A22498-25AVN-101 HCl 25mg

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