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MI-1851

CAT: 0804-HY-150737-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-150737-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity[1][2].
CAS Number
2417283-44-2
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mi-1851.html
Purity
95.92
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC(NCC1=CC=C(C=C1)CC(N[C@H](C(N[C@H](C(N[C@H](C(NCC2=CC=C(C=C2)C(N)=N)=O)CCONC(N)=N)=O)C(C)(C)C)=O)CCONC(N)=N)=O)=N
Molecular Formula
C34H53N15O6
Molecular Weight
767.88
References & Citations
[1] Erzsébet Pászti-Gere, et al. In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicity. Biomed Pharmacother. 2022 Jul;151:113124.|[2]Dorothea Bestle, et al. TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. Life Sci Alliance. 2020 Jul 23;3 (9) :e202000786.|[3]Thuy Van Lam van, et al. The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin. ACS Med Chem Lett. 2021 Feb 9;12 (3) :426-432.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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