1,3-PBIT (dihydrobromide)

CAT:

804-HY-120865

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CAS Number: 200716-66-1
UNSPSC Description: 1,3-PBIT is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 μM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.
Target Antigen: NO Synthase
Type: Reference compound
Related Pathways: Immunology/Inflammation
Applications: COVID-19-immunoregulation
Field of Research: Inflammation/Immunology
Assay Protocol: https://www.medchemexpress.com/1-3-pbit-dihydrobromide.html
Smiles: NC(SCCC1=CC(CCSC(N)=N)=CC=C1)=N.Br.Br
Molecular Weight: 444.25
References & Citations: [1]Garvey, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J. Biol. Chem. 269(43), 26669-26676 (1994).
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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