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Immethridine (dihydrobromide)

CAT: 0804-HY-108058A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108058A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Immethridine (dihydrobromide) is a potent and highly selective histamine H (3) receptor agonist with pKi and pEC50 value of 9.07 and 9.74, respectively. Immethridine can be used for the research of myocardial ischemia, inflammatory, and gastric acid related diseases research[1].
CAS Number
699020-93-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/immethridine-dihydrobromide.html
Solubility
10 mM in DMSO
Smiles
[H]Br.[H]Br.C1(CC2=CN=CN2)=CC=NC=C1
Molecular Formula
C9H11Br2N3
Molecular Weight
321.01
Precautions
P261-P280-P302+P352
References & Citations
[1]Shi Y, et al. Immethridine, histamine H3-receptor (H3R) agonist, alleviated experimental autoimmune encephalomyelitis via inhibiting the function of dendritic cells. Oncotarget. 2017 Aug 24;8 (43) :75038-75049.|[2]Kitbunnadaj R, et al. Identification of 4- (1H-imidazol-4 (5) -ylmethyl) pyridine (immethridine) as a novel, potent, and highly selective histamine H (3) receptor agonist. J Med Chem. 2004 May 6;47 (10) :2414-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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