Immethridine (dihydrobromide)

• UNSPSC Description:

  Immethridine (dihydrobromide) is a potent and highly selective histamine H(3) receptor agonist with pKi and pEC50 value of 9.07 and 9.74, respectively. Immethridine can be used for the research of myocardial ischemia, inflammatory, and gastric acid related diseases research[1].

• Target Antigen:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/immethridine-dihydrobromide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H]Br.[H]Br.C1(CC2=CN=CN2)=CC=NC=C1

• Molecular Weight:

  321.01

• References & Citations:

  [1]Shi Y, et al. Immethridine, histamine H3-receptor (H3R) agonist, alleviated experimental autoimmune encephalomyelitis via inhibiting the function of dendritic cells. Oncotarget. 2017 Aug 24;8(43):75038-75049.|[2]Kitbunnadaj R, et al. Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist. J Med Chem. 2004 May 6;47(10):2414-7.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  699020-93-4