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PBIT

CAT: 0804-HY-101451-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101451-01Size:5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1) histone demethylase with an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC50s of 6 μM and 4.9 μM, respectively[1].
CAS Number
[2514-30-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pbit.html
Purity
99.46
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=C(C)C=C2)SC3=C1C=CC=C3
Molecular Formula
C14H11NOS
Molecular Weight
241.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288 (13) :9408-17.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM5

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