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Imetit (dihydrobromide)

CAT: 0804-HY-101173-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101173-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM) [1][2][3].
CAS Number
32385-58-3
Product Name Alternative
VUF 8325 (dihydrobromide) ; SKF 91105 (dihydrobromide)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/imetit-dihydrobromide.html
Purity
98.16
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
NC(SCCC1=CN=CN1)=N.Br.Br
Molecular Formula
C6H12Br2N4S
Molecular Weight
332.06
Precautions
H302, H315, H319, H335
References & Citations
[1]Liu C, et al. Cloning and pharmacological characterization of a fourth histamine receptor (H (4) ) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59 (3) :420-6.|[2]Ling P, et al. Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol. 2004 May;142 (1) :161-71.|[3]Garbarg M, et al. S-[2- (4-imidazolyl) ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J Pharmacol Exp Ther. 1992 Oct;263 (1) :304-10.|[4]Farzin D, et al. Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rat. Eur J Pharmacol. 2000 Sep 15;404 (1-2) :169-74.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor; H4 Receptor

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