TP-024

CAT: 0804-HY-101787-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-101787-02Size:10 mM - 1 mL

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Description

TP-024 (FTBMT), a chemical probe, is a selective GPR52 agonist with an EC50 of 75 nM[1]. TP-024 has antipsychotic and procognitive properties[2].

CAS Number

1358575-02-6

Product Name Alternative

FTBMT

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

GPR52

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tp-024.html

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N)C1=CC=C(N2C(C)=NC(CC3=CC(C(F)(F)F)=CC(F)=C3)=N2)C=C1C

Molecular Formula

C19H16F4N4O

Molecular Weight

392.35

Precautions

H315, H319, H335

References & Citations

[1]Tokumaru K, et al. Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg Med Chem. 2017 Jun 15;25 (12) :3098-3115.|[2]Nishiyama K, et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017 Nov;363 (2) :253-264.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

4-(3-(3-fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide

selective GPR52 agonist; structure in first source

CAS Number	1358575-02-6
PubChem CID	56649300
IUPAC Name	4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1,2,4-triazol-1-yl]-2-methylbenzamide
Molecular Formula	C19H16F4N4O
Molecular Weight	392.3
XLogP	4.2
Topological Polar Surface Area	73.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Heavy Atom Count	28
Formal Charge	0
Complexity	561

SMILES

CC1=C(C=CC(=C1)N2C(=NC(=N2)CC3=CC(=CC(=C3)F)C(F)(F)F)C)C(=O)N

InChI

InChI=1S/C19H16F4N4O/c1-10-5-15(3-4-16(10)18(24)28)27-11(2)25-17(26-27)8-12-6-13(19(21,22)23)9-14(20)7-12/h3-7,9H,8H2,1-2H3,(H2,24,28)

InChIKey

TYXSIXOYTBHZFA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1358575-02-6

CID: 56649300

Formula: C19H16F4N4O

MW: 392.3

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	392.3
XLogP3	4.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	392.12602379
Monoisotopic Mass	392.12602379
Topological Polar Surface Area	73.8 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	561
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-115726A-01	(-) -FRM-024
HY-116167	RY 024
HY-P990590-01	GFB-024
HY-100254	TAK-024
HY-107390-01	AX-024
HY-115726-01	FRM-024
HY-111861	SNIPER (ABL) -024
HY-107390A-01	AX-024 (hydrochloride)
HY-138561	EFdA-TP
HY-119127	TP-680

Alternative Products

Catalog	Name
E8126	TP-024
BA8597-1	FRM-024
B5192-1	HS 024
VEC54473-01	AX-024
T26666-01	ASM-024
T13065-01	TAK-024
T77488-01	GFB-024
MBS3605766-01	ZLN-024

TP-024

Chemical Information

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