AX-024

CAT: 0804-HY-107390-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107390-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
CAS Number
[1370544-73-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IFNAR; Interleukin Related; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/AX-024.html
Purity
99.73
Solubility
DMSO : 35 mg/mL (ultrasonic; warming) |Ethanol : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C(OC2)C(C(C3=CC=C(F)C=C3)=C2CN4CCCC4)=C1
Molecular Formula
C21H22FNO2
Molecular Weight
339.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Borroto A, et al. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci Transl Med. 2016 Dec 21;8 (370) :370ra184.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
IL-10; IL-17; IL-6; TNFRSF5/CD40

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