FRM-024

• UNSPSC Description:

  FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease.

• Target Antigen:

  γ-secretase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling;Stem Cell/Wnt

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/frm-024.html

• Purity:

  99.45

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  ClC1=CC=C(C=C1)[C@H]2[C@@H](C3CC3)ON=C(C4=CC=C(N5C=C(N=C5)C)C(OC)=N4)N2

• Molecular Weight:

  423.90

• References & Citations:

  [1]Bursavich MG, et al. Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator. J Med Chem. 2021 Oct 14;64(19):14426-14447.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  2085780-87-4