(-) -FRM-024

• Description :

  (-) -FRM-024 is the (-) -isomer of FRM-024, a potent CNS-penetrant gamma secretase modulator that can be utilized in Alzheimer’s disease research[1].

• Product Name Alternative :

  BMS 234303-01

• UNSPSC :

  12352005

• Target :

  γ-secretase

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; Stem Cell/Wnt

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/minus-frm-024.html

• Purity :

  98.27

• Smiles :

  ClC1=CC=C(C=C1)[C@H]2[C@@H](C3CC3)ON=C(C4=CC=C(N5C=C(N=C5)C)C(OC)=N4)N2

• Molecular Formula :

  C22H22ClN5O2

• Molecular Weight :

  423.90

• References & Citations :

  [1]Bursavich MG, et al. Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator. J Med Chem. 2021 Oct 14;64 (19) :14426-14447.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2085780-85-2]