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IL12 B Recombinant Protein

CAT: 0223-96-554Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-96-554Size:0.02 mg
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Background
Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40) . IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. Interleukin-12 subunit beta (IL12B) also known as NKSF2, CLMF2 and P40. Interleukin-12 subunit beta has been shown to interact with IL23. A large excess of monomeric IL12B is also secreted by the cells producing IL12, and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis. In addition, studies have revealed that the promoter polymorphism of this gene is implicated in the severity of atopic and non-atopic asthma in children.
CAS Number
9000-83-3
NCBI Gene ID
3593
Swiss Prot
P29460
Accession Number
AAH67499
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Immunology, Infectious Disease, Innate Immunity, Signal Transduction
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
61.3 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
NCBI Organism
Homo sapiens
Background Reference 01
Kaliński P, et al., 1997, J. Immunol. 159 : 28–35.
Background Reference 02
Chehimi J, et al., 1993, Eur J Immunol., 23 (8) :1826-30.
Background Reference 03
Thierfelder WE, et al., Nature., 382 (6587) :171-4.
Background Reference 04
Oppmann B., et al., 2000, Immunity (UNITED STATES) 13 (5) : 715–25.
Other Product Names
IL12B, CLMF, CLMF2, NKSF, NKSF2, p40
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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