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Granzyme B Recombinant Protein

CAT: 0223-40-125-01Size: 0.002 mgDry Ice: NoHazardous: No
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CAT#:0223-40-125-01Size:0.002 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Granzyme B is a cysteine protease found in the cytoplasmic granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme B is required for the induction of target cell lysis, which occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms. Proteolytic cleavage of substrates by Granzyme B takes place primarily after aspartic acid residues. Recombinant murine Granzyme B is a glycosylated 227 amino acid protein, comprising the mature active portion of the murine Granzyme B precursor. The apparent molecular weight is 28.9 kDa by mass spectrometry.
NCBI Gene ID
14939
Swiss Prot
P04187
Accession Number
NP_038570.1
Type
Recombinant Proteins
Source
Baculovirus
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized Granzyme B recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Granzyme B is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Granzyme B recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Granzyme B
NCBI Organism
Mus musculus
Other Product Names
GZB, CCP1, Ctla1, Ctla-1, AI553453, CCP-1/C11, CTLA-1
Species
Murine
Protein ID
7305123
Physical Properties
Lyophilized

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