GITRL, Soluble Recombinant Protein

CAT: 0223-90-004Size: 50 µgDry Ice: NoHazardous: No
CAT#:0223-90-004Size:50 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis) . GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
CAS Number
9000-83-3
NCBI Gene ID
240873
Swiss Prot
O35608
Accession Number
Q7TS55
Tag
DDDDK Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Immunology
Concentration
0.5mg/ml
Buffer
0.2um-filtered solution in 10mM glycine, pH 10.0.
Shipping Conditions
Blue Ice
Storage Conditions
Working aliquots are stable for up to 3 months when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 18
NCBI Organism
Mus musculus
Other Product Names
Glucocorticoid-induced TNF Receptor Ligand, AITRL, Activation-inducible TNF-related Ligand, TNFSF18
Species
Mouse
Protein ID
81894654
Physical Properties
Liquid

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