GITRL, Soluble Recombinant Protein

• Background:

  GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis) . GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

• NCBI Gene ID:

  240873

• Swiss Prot:

  O35608

• Accession Number:

  Q7TS55

• Tag:

  DDDDK Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Immunology

• Concentration:

  0.5mg/ml

• Buffer:

  0.2um-filtered solution in 10mM glycine, pH 10.0.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 18

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Glucocorticoid-induced TNF Receptor Ligand, AITRL, Activation-inducible TNF-related Ligand, TNFSF18

• Species:

  Mouse

• Protein ID:

  81894654

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3