GITRL Antibody

CAT: 0223-3591-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-3591-01Size:0.02 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GITRL Antibody: The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κ B and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-κ B, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κ B activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.
NCBI Gene ID
8995
Swiss Prot
Q9UNG2
Accession Number
Q9UNG2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
GITRL antibody was raised against purified recombinant human GITR ligand.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Chemokines & Cytokines
Purification
GITRL Antibody is Protein A purified.
Positive Control
Cat. No. 1208 - THP-1 Cell Lysate
Concentration
1 mg/mL
Buffer
GITRL Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
GITRL antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TNFSF18
Positive Control 2
Cat. No. 17-008 - THP-1 Cell Slide
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 18
NCBI Organism
Homo sapiens
Background Reference 01
Gaur U, Aggarwal BB. Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. Biochem. Pharmacol. 2003; 66:1403-8.
Background Reference 02
Ronchetti S, Nocentini G, Riccardi C, et al. Role of GITR in activation response of T lymphocytes.Blood 2002; 100:350-2.
Background Reference 03
Shimizu J, Yamakai S, Takahashi T, et al. Stimulation of CD25 (+) CD4 (+) regulatory T cells through GITR breaks immunological self- tolerance. Nat. Immunol. 2002;3:135-42.
Background Reference 04
Gurney AL, Marsters SA, Huang A, et al. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 1999; 9:215-218.
Other Product Names
GITRL Antibody: TL6, AITRL, GITRL, hGITRL, TL6, UNQ149/PRO175, Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand
Tested Applications
ELISA, WB, ICC
Protein ID
13124621
Physical Properties
Liquid

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