GITRL Antibody

• Background :

  GITRL Antibody: The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κ B and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-κ B, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κ B activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.

• NCBI Gene ID :

  8995

• Swiss Prot :

  Q9UNG2

• Accession Number :

  Q9UNG2

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  GITRL antibody was raised against purified recombinant human GITR ligand.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Chemokines & Cytokines

• Purification :

  GITRL Antibody is Protein A purified.

• Positive Control :

  Cat. No. 1208 - THP-1 Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  GITRL Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  GITRL antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  TNFSF18

• Positive Control 2 :

  Cat. No. 17-008 - THP-1 Cell Slide

• NCBI Official Name :

  Tumor necrosis factor (ligand) superfamily, member 18

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Gaur U, Aggarwal BB. Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. Biochem. Pharmacol. 2003; 66:1403-8.

• Background Reference 02 :

  Ronchetti S, Nocentini G, Riccardi C, et al. Role of GITR in activation response of T lymphocytes.Blood 2002; 100:350-2.

• Background Reference 03 :

  Shimizu J, Yamakai S, Takahashi T, et al. Stimulation of CD25 (+) CD4 (+) regulatory T cells through GITR breaks immunological self- tolerance. Nat. Immunol. 2002;3:135-42.

• Background Reference 04 :

  Gurney AL, Marsters SA, Huang A, et al. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 1999; 9:215-218.

• Other Product Names :

  GITRL Antibody: TL6, AITRL, GITRL, hGITRL, TL6, UNQ149/PRO175, Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand

• Tested Applications :

  ELISA, WB, ICC

• Protein ID :

  13124621

• Physical Properties :

  Liquid