GITRL Antibody

• Background:

  GITRL Antibody: The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κ B and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-κ B, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κ B activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.

• NCBI Gene ID:

  8995

• Swiss Prot:

  Q9UNG2

• Accession Number:

  Q9UNG2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  GITRL antibody was raised against purified recombinant human GITR ligand.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Chemokines & Cytokines

• Purification:

  GITRL Antibody is Protein A purified.

• Positive Control:

  Cat. No. 1208 - THP-1 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  GITRL Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  GITRL antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  TNFSF18

• Positive Control 2:

  Cat. No. 17-008 - THP-1 Cell Slide

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 18

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gaur U, Aggarwal BB. Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. Biochem. Pharmacol. 2003; 66:1403-8.

• Background Reference 02:

  Ronchetti S, Nocentini G, Riccardi C, et al. Role of GITR in activation response of T lymphocytes.Blood 2002; 100:350-2.

• Background Reference 03:

  Shimizu J, Yamakai S, Takahashi T, et al. Stimulation of CD25 (+) CD4 (+) regulatory T cells through GITR breaks immunological self- tolerance. Nat. Immunol. 2002;3:135-42.

• Background Reference 04:

  Gurney AL, Marsters SA, Huang A, et al. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 1999; 9:215-218.

• Other Product Names:

  GITRL Antibody: TL6, AITRL, GITRL, hGITRL, TL6, UNQ149/PRO175, Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand

• Tested Applications:

  ELISA, WB, ICC

• Protein ID:

  13124621

• Physical Properties:

  Liquid