Complement component C8 gamma Recombinant Protein

• Background :

  Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Patients lacking C8 are susceptible to certain bacterial infections.

• NCBI Gene ID :

  733

• Swiss Prot :

  P07360

• Accession Number :

  P07360

• Tag :

  N-6 His tag

• Type :

  Recombinant Proteins

• Source :

  E. coli

• Buffer :

  Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions :

  Dry Ice

• Calculated Molecular Weight :

  22.6 kD

• Applications Notes :

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name :

  Complement component 8, gamma polypeptide

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  Complement component C8 gamma chain, C8G

• Species :

  Human

• Protein ID :

  767983919

• Physical Properties :

  Liquid

• CAS Number :

  9000-83-3