Complement component C8 gamma Recombinant Protein

• Background:

  Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Patients lacking C8 are susceptible to certain bacterial infections.

• NCBI Gene ID:

  733

• Swiss Prot:

  P07360

• Accession Number:

  P07360

• Tag:

  N-6 His tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Buffer:

  Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  22.6 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Complement component 8, gamma polypeptide

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Complement component C8 gamma chain, C8G

• Species:

  Human

• Protein ID:

  767983919

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3