Complement Component C5a Recombinant Protein

CAT: 0223-11-315Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-11-315Size:0.1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Complement Component C5a (C5a) is also known as C5, and is a protein fragment released from complement component C5., is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.
CAS Number
9000-83-3
NCBI Gene ID
102125658
Accession Number
XP_015292262.1
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>90% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
34.6 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 34.6 kDa. The protein migrates as 38-40 kDa and 41-44 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
ComplementC5
NCBI Organism
Macaca fascicularis
Background Reference 01
Gerard, C. and N.P. Gerard, 1994, Annu. Rev. Immunol.12:775.
Background Reference 02
Monk, PN. et al., 2007, British Journal of Pharmacology. 152: 429-48.
Background Reference 03
Reis ES, et al., 2011, Brain Behav Immun. Apr 23.
Background Reference 04
Bergseth G, et al., 2011, Ann Thorac Surg., 91 (2) :527-33.
Other Product Names
C5a, Complement Component 5a
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized

Related Products

CatalogName
11-258Complement Component C2 Recombinant Protein
92-710Complement Component C3a Recombinant Protein
91-061Complement Component C5 Recombinant Protein
92-689Complement Component C3a Recombinant Protein
92-260Complement component C8 gamma Recombinant Protein
40-690C5a Recombinant Protein
43-394PComplement component 7 Peptide
43-394Complement component 7 Antibody
11-259Complement C5 Recombinant Protein
11-357Complement C5 Recombinant Protein

Alternative Products

CatalogName
MBS2553469-01Recombinant Mouse Complement Component C5 Protein
NBP1-86527PEPComplement Component C1r Recombinant Protein Antigen
NBP1-87440PEPComplement Component C9 Recombinant Protein Antigen
NBP1-89885PEPComplement Component C1qC Recombinant Protein Antigen
PROTP01031-01Complement Component C5a Human Recombinant Protein
NBP1-86439PEPComplement Component C1s Recombinant Protein Antigen
PROTP06684-01Complement Component C5a Mouse Recombinant Protein
NBP1-88314PEPComplement Component C1rLP Recombinant Protein Antigen
NBP3-21274PEPComplement Component C5aR1 Recombinant Protein Antigen
abx263216-01Complement Component C3c Protein

Popular Products