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Complement Component C2 Recombinant Protein

CAT: 0223-11-258Size: 0.05 mgDry Ice: NoHazardous: No
CAT#: 11-258Size: 0.05 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C2 is a major histocompatibility complex class-III protein. Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. The lectin (LP) and classical (CP) pathways are two of the three main activation cascades of the complement system. These pathways start with recognition of different pathogen- or danger-associated molecular patterns and include identical steps of proteolytic activation of complement component C4, formation of the C3 proconvertase C4b2, followed by cleavage of complement component C2 within C4b2 resulting in the C3 convertase C4b2a.
CAS Number
9000-83-3
NCBI Gene ID
717
Swiss Prot
P06681
Accession Number
NP_000054.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>90% as determined by SDS-PAGE.
Buffer
20 mM Tris, 150 mM NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
83.0 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 83.0 kDa. The protein migrates as 95-110 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
NCBI Official Name
ComplementC2
NCBI Organism
Homo sapiens
Background Reference 01
Mortensen S, et al. 2016. J Biol Chem. 291 (32) :16494-507.
Background Reference 02
Yaseen S, et al. 2017. FASEB J. 31 (5) :2210-2219.
Other Product Names
C2, Complement C2, Complement Component C2
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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