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Complement Component C5a Recombinant Protein

CAT: 0223-11-368Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-11-368Size:0.1 mg
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Background
Complement Component C5a (C5a) is also known as C5, and is a protein fragment released from complement component C5., is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.
CAS Number
9000-83-3
Accession Number
NP_034536.2
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
10.9 kDa
Applications Notes
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 10.9 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background Reference 01
Gerard, C. and N.P. Gerard, 1994, Annu. Rev. Immunol.12:775.
Background Reference 02
Monk, PN. et al., 2007, British Journal of Pharmacology. 152: 429-48.
Background Reference 03
Reis ES, et al., 2011, Brain Behav Immun. Apr 23.
Background Reference 04
Bergseth G, et al., 2011, Ann Thorac Surg., 91 (2) :527-33.
Other Product Names
C5a, Complement Component 5a
Tested Applications
ELISA, WB
Species
Mouse
Physical Properties
Lyophilized

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