GRB2 Antibody

• Background:

  GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway.

• NCBI Gene ID:

  2885

• Swiss Prot:

  P62993

• Accession Number:

  P62993

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from human GRB2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Xenopus, Chicken, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  25 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GRB2

• NCBI Official Name:

  Growth factor receptor-bound protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kondo, A., J. Biol. Chem. 283 (3), 1428-1436 (2008) Morimatsu, M., Proc. Natl. Acad. Sci. U.S.A. 104 (46), 18013-18018 (2007) Martinez, N., Cell. Signal. 19 (11), 2277-2285 (2007)

• Other Product Names:

  Growth factor receptor-bound protein 2, Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2, GRB2, ASH

• Tested Applications:

  WB, IHC-P

• Protein ID:

  51702266

• Physical Properties:

  Liquid