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Dasatinib-d4

CAT: 0804-HY-10181S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10181S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dasatinib-d4 (BMS-354825-d4) is deuterium labeled Dasatinib. Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC50s of [1][2]. Dasatinib also induces apoptosis and autophagy.
CAS Number
1160297-08-4
Product Name Alternative
BMS-354825-d4
UNSPSC
12352005
Target
Apoptosis; Autophagy; Bcr-Abl; Isotope-Labeled Compounds; Src
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Purity
97.54
Smiles
OC([2H])([2H])C([2H])([2H])N(CC1)CCN1C2=NC(C)=NC(NC3=NC=C(C(NC4=C(C=CC=C4Cl)C)=O)S3)=C2
Molecular Formula
C22H22D4ClN7O2S
Molecular Weight
492.03
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Lombardo LJ, et al. Discovery of N- (2-chloro-6-methyl- phenyl) -2- (6- (4- (2-hydroxyethyl) - piperazin-1-yl) -2-methylpyrimidin-4- ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004 Dec 30;47 (27) :6658-61.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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