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Dasatinib (GMP)

CAT: 0804-HY-10181GSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10181GSize:1 Each
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Description
Dasatinib (BMS-354825) (GMP) is a GMP-grade Dasatinib. GMP-grade small molecules can be used as adjuvant agents in cell therapy. Dasatinib (BMS-354825) is an orally active, ATP-competitive, dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Ki values ​​for Src and Bcr-Abl are 16 pM and 30 pM, respectively. Dasatinib inhibits Bcr-Abl and Src with IC50 values ​​of less than 1.0 nM and 0.5 nM, respectively. Dasatinib also induces apoptosis and autophagy[1].
CAS Number
302962-49-8
Product Name Alternative
BMS-354825 (GMP)
UNSPSC
12352005
Hazard Statement
H315-H318-H351-H361-H372-H401-H410
Target
Apoptosis; Autophagy; Bcr-Abl; Src
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dasatinib-gmp.html
Smiles
O=C(C1=CN=C(S1)NC2=NC(C)=NC(N3CCN(CC3)CCO)=C2)NC4=C(C=CC=C4Cl)C
Molecular Formula
C22H26ClN7O2S
Molecular Weight
488.01
Precautions
P260-P264-P270-P273-P280-P302+P352-P362-P391-P405-P501
References & Citations
[1]Lombardo L J, et al. Discovery of N- (2-chloro-6-methyl-phenyl) -2- (6- (4- (2-hydroxyethyl) -piperazin-1-yl) -2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays[J]. Journal of medicinal chemistry, 2004, 47 (27) : 6658-6661.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

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