Hydroxymethyl dasatinib

• Description:

  Hydroxymethyl dasatinib (M24), a benzylhydroxy metabolite of Dasatinib (HY-10181), exhibits an IC50 of 46.7nM in K562 CML cells[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H318, H351, H361, H372, H401, H410

• Target:

  Apoptosis; Bcr-Abl; Drug Metabolite; Src

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/hydroxymethyl-dasatinib.html

• Purity:

  99.92

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=C(C=CC=C1Cl)CO)C2=CN=C(S2)NC3=CC(N4CCN(CC4)CCO)=NC(C)=N3

• Molecular Formula:

  C22H26ClN7O3S

• Molecular Weight:

  504.00

• Precautions:

  H315, H318, H351, H361, H372, H401, H410

• References & Citations:

  [1]Lisa J Christopher, et al. Metabolism and disposition of dasatinib after oral administration to humans. Drug Metab Dispos. 2008 Jul;36 (7) :1357-64.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [910297-58-4]