Pro-Dasatinib

• Description:

  Pro-Dasatinib (compound 2j), an amino acid analog of Dasatinib (HY-10181), is a potent Src/Abl kinase inhibitor. Pro-Dasatinib has antiproliferative activity against K652 leukemia cancer cells with an IC50 of 0.21 nM.

• UNSPSC:

  12352005

• Target:

  Bcr-Abl; Src

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Purity:

  98.06

• Smiles:

  O=C([C@@H]1CCCN1)N(CC2)CCN2C3=NC(C)=NC(NC4=NC=C(C(NC5=C(C=CC=C5Cl)C)=O)S4)=C3

• Molecular Formula:

  C25H29ClN8O2S

• Molecular Weight:

  541.07

• References & Citations:

  [1]Buchappa, G.et al. (2016) . Design and Synthesis of Novel Dasatinib Analogues. Asian Journal of Chemistry, 28 (6), 1275-1280.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2468065-01-0]