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Dasatinib (Standard)

CAT: 0804-HY-10181R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10181R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dasatinib (Standard) is the analytical standard of Dasatinib. This product is intended for research and analytical applications. Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC50s of [1]. Dasatinib also induces apoptosis and autophagy.
CAS Number
302962-49-8
Product Name Alternative
BMS-354825 (Standard)
UNSPSC
12352005
Hazard Statement
H315-H318-H351-H361-H372-H401-H410
Target
Apoptosis; Autophagy; Bcr-Abl; Reference Standards; Src
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dasatinib-standard.html
Smiles
O=C(C1=CN=C(S1)NC2=NC(C)=NC(N3CCN(CC3)CCO)=C2)NC4=C(C=CC=C4Cl)C
Molecular Formula
C22H26ClN7O2S
Molecular Weight
488.01
Precautions
P260-P264-P270-P273-P280-P302+P352-P362-P391-P405-P501
References & Citations
[1]Lombardo LJ, et al. Discovery of N- (2-chloro-6-methyl- phenyl) -2- (6- (4- (2-hydroxyethyl) - piperazin-1-yl) -2-methylpyrimidin-4- ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004 Dec 30;47 (27) :6658-61.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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