Lei-Dab7

CAT: 0804-HY-P1424Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P1424Size:1 Each
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Description
Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a Kd of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels[1][2].
CAS Number
[1061556-49-7]
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lei-dab7.html
Solubility
10 mM in DMSO
Smiles
[C@H](CC1=CC=CC=C1)(C(N[C@@H]2C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCN)C(=O)N[C@@]3(C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@]4(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@](CSSC2)(C(=O)N[C@@]([C@H](CC)C)(C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@](CSSC3)(C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CN=CN5)C(N)=O)=O)CCCCN)=O)[C@H](C)C)=O)CSSC4)[H])[H])[H])[H])[H])=O)NC([C@H](C)N)=O
Molecular Formula
C141H236N46O39S6
Molecular Weight
3392.06
References & Citations
[1]Sabrine Aidi-Knani, et al. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur J Pharmacol. 2015 Apr 5;752:106-11.|[2]V G Shakkottai, et al. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16;276 (46) :43145-51.|[3]Bedel Mpari, et al. Small-conductance Ca (2+) -activated K (+) channels: Heterogeneous affinity in rat brain structures and cognitive modulation by specific blockers. Eur J Pharmacol. 2008 Jul 28;589 (1-3) :140-8.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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