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Leiurotoxin-1 Dab7

CAT: 0466-LED01-00100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0466-LED01-00100Size:0.1 mg
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Description
Leiuorotoxin-Dab7 (Lei-Dab7) is a mutated version of Leiurotoxin, a peptide identified from the venom of the scorpion Leiurus quinquestriatus hebraeus. The Dab amino acid in position 7 confers to this compound a high selectivity for SK2 channels among other channels. Lei-Dab7 exhibits > 200 fold selectivity for SK2 over SK1, SK3, IK, Kv and Kir channels. The IC50 for SK2 is about 3 nM.
Specifications
SK2 channel blocker
Target
K channels
Sequence
AFCNLRZCQLSCRSLGLLGKCIGDKCECVKH (avec Z=Dab)
Peptide Number
LED01
Disulfide Bonds
Cys3-Cys21; Cys8-Cys26; Cys12-Cys28
N Terminal Sequence
H
C Terminal Sequence
NH2

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