L-DABA

• Description :

  L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

• Product Name Alternative :

  L-2,4-Diaminobutyric acid

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite; GABA Receptor

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/L-DABA.html

• Purity :

  99.89

• Solubility :

  H2O : 1 mg/mL (ultrasonic)

• Smiles :

  O=C(O)[C@@H](N)CCN

• Molecular Formula :

  C4H10N2O2

• Molecular Weight :

  118.13

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Ronquist G, et al. Antitumor activity of L-2,4 diaminobuturic acid against mouse fibrosarcoma cells in vitro and in vivo. J Cancer Res Clin Oncol. 1980;96 (3) :259-68.|[2]Beart PM, et al. l-2,4-Diaminobutyric acid and the GABA system. Neurosci Lett. 1977 Jul;5 (3-4) :193-8.|[3]Panasci L, et al. The cytolytic effect of L-2,4 diaminobutyric acid with malignant glioma cells and fibroblasts. Cancer Chemother Pharmacol. 1988;21 (2) :143-4.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [1758-80-1]