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AR-C117977

CAT: 0804-HY-114602Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114602Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AR-C117977 is a potent monocarboxylate transporter (MCT1) inhibitor. AR-C117977 prolongs the survival of skin and heart sllograft. AR-C117977 inhibits the development of transplant arteriosclerosis in aortic allografts partially, but was unable to inhibit alloantibody production after transplantation. AR-C117977 shows potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse[1].
CAS Number
216685-07-3
UNSPSC
12352005
Target
Monocarboxylate Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ar-c117977.html
Smiles
O=C1N(CC(C)C)C2=C(C(SCCCO)=C(CC3=C4C=CC=CC4=CC=C3)S2)C(N1C)=O
Molecular Formula
C25H28N2O3S2
Molecular Weight
468.63
References & Citations
[1]Bueno V, et al. The specific monocarboxylate transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival in the mouse. Transplantation. 2007 Nov 15;84 (9) :1204-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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