AR-C117977

• Description :

  AR-C117977 is a potent monocarboxylate transporter (MCT1) inhibitor. AR-C117977 prolongs the survival of skin and heart sllograft. AR-C117977 inhibits the development of transplant arteriosclerosis in aortic allografts partially, but was unable to inhibit alloantibody production after transplantation. AR-C117977 shows potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse[1].

• UNSPSC :

  12352005

• Target :

  Monocarboxylate Transporter

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ar-c117977.html

• Smiles :

  O=C1N(CC(C)C)C2=C(C(SCCCO)=C(CC3=C4C=CC=CC4=CC=C3)S2)C(N1C)=O

• Molecular Formula :

  C25H28N2O3S2

• Molecular Weight :

  468.63

• References & Citations :

  [1]Bueno V, et al. The specific monocarboxylate transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival in the mouse. Transplantation. 2007 Nov 15;84 (9) :1204-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [216685-07-3]