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CNQX (disodium)

CAT: 0804-HY-15066A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15066A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist[1]. CNQX disodium blocks the expression of fear-potentiated startle in rats[5].
CAS Number
479347-85-8
Product Name Alternative
FG9065 (disodium)
UNSPSC
12352005
Hazard Statement
H302, H319, H372, H410
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cnqx-disodium.html
Purity
99.95
Solubility
DMSO : 10.53 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 70°C)
Smiles
N#CC1=CC2=C([N-]C(C([N-]2)=O)=O)C=C1[N+]([O-])=O.[Na+].[Na+]
Molecular Formula
C9H2N4Na2O4
Molecular Weight
276.12
Precautions
H302, H319, H372, H410
References & Citations
[1]T Honoré, et al. Quinoxalinediones: Potent Competitive non-NMDA Glutamate Receptor Antagonists. Science. 1988 Aug 5;241 (4866) :701-3.|[2]Alford S, et al. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 1990 Jan 8;506 (2) :297-302.|[3]Neuman RS, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro. Neurosci Lett. 1988 Sep 23;92 (1) :64-8.|[4]Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59 (1) :5-8.|[5]Pia Bäckström, et al. Attenuation of Cocaine-Seeking Behaviour by the AMPA/kainate Receptor Antagonist CNQX in Rats. Psychopharmacology (Berl) . 2003 Feb;166 (1) :69-76.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor; Kainate Receptor
Citation 01
Nat Commun. 2025 May 16;16 (1) :4560.|Acta Biomater. 2022 Oct 15:152:255-272.|Biomed Pharmacother. 2022 Jan:145:112446.|Cell Death Dis. 2022 Sep 12;13 (9) :786.|Cell Rep. 2025 May 14;44 (5) :115712.|Environ Sci Technol. 2023 Aug 22;57 (33) :12222-12233.|Front Cell Neurosci. 2019 Jun 25:13:276.|J Cell Mol Med. 2021 Aug;25 (15) :7342-7353.|J Integr Neurosci. 2022 Jun 28;21 (4) :121.|J Neurosci. 2024 Apr 10;44 (15) :e2062232024.|Nat Commun. 2024 May 15;15 (1) :4122.|Nat Neurosci. 2023 May;26 (5) :751-764.|PLoS Biol. 2025 Jan 27;23 (1) :e3003011.|SSRN. 2025 Jun 18.

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