E7766 (disodium)

• UNSPSC Description:

  E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities[1].

• Target Antigen:

  STING

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/e7766-disodium.html

• Solubility:

  10 mM in DMSO

• Smiles:

  F[C@@H]1[C@H](O[P@]2(S)=O)[C@@H](CO[P@]3(S)=O)O[C@H]1[N@]4C5=NC=NC(NC/C=C/CNC6=C(N=C[N@]7[C@@H]8O[C@H](CO2)[C@@H](O3)[C@H]8F)C7=NC=N6)=C5N=C4.[Na].[Na]

• Molecular Weight:

  792.58

• References & Citations:

  [1]Dae-Shik Kim, et al. E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  2242636-28-6