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Oglufanide (disodium)

CAT: 0804-HY-13718ASize: 1 EachDry Ice: NoHazardous: No
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Description
Oglufanide (H-Glu-Trp-OH) disodium is a dipeptide immunomodulator isolated from calf thymus. Oglufanide disodium inhibits vascular endothelial growth factor (VEGF) . Oglufanide disodium can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide disodium shows antitumor and anti-angiogenesis activities[1][2][3].
CAS Number
237068-57-4
Product Name Alternative
H-Glu-Trp-OH (disodium) ; L-Glutamyl-L-tryptophan (disodium)
UNSPSC
12352005
Target
Endogenous Metabolite; HCV; VEGFR
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/oglufanide-disodium.html
Smiles
O=C(O[Na])CC[C@H](N)C(N[C@H](C(O[Na])=O)CC1=CNC2=CC=CC=C12)=O
Molecular Formula
C16H17N3Na2O5
Molecular Weight
377.30
References & Citations
[1]Bayes M, et al. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jul-Aug;27 (6) :411-61.|[2]Nagendra Kumar Kaushik, et al. Biomedical importance of indoles. Molecules. 2013 Jun 6;18 (6) :6620-62.|[3]Noy A, et al. Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team. J Clin Oncol. 2005 Feb 10;23 (5) :990-8.|[4]Smith DL, et al. Natural killer cell cytolytic activity is necessary for in vivo antitumor activity of the dipeptide L-glutamyl-L-tryptophan. Int J Cancer. 2003 Sep 10;106 (4) :528-533.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Human Endogenous Metabolite

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