Products for Research Use Only
RegisterLogin

CNQX

CAT: 0804-HY-15066-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-15066-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist[1]. CNQX blocks the expression of fear-potentiated startle in rats[5].
CAS Number
115066-14-3
Product Name Alternative
FG9065
UNSPSC
12352005
Hazard Statement
H410
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CNQX.html
Purity
99.65
Solubility
DMSO : 20 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(NC2=CC([N+]([O-])=O)=C(C#N)C=C2N1)=O
Molecular Formula
C9H4N4O4
Molecular Weight
232.15
Precautions
H410
References & Citations
[1]T Honoré, et al. Quinoxalinediones: Potent Competitive non-NMDA Glutamate Receptor Antagonists. Science. 1988 Aug 5;241 (4866) :701-3.|[2]Neuman RS, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro. Neurosci Lett. 1988 Sep 23;92 (1) :64-8.|[3]Alford S, et al. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 1990 Jan 8;506 (2) :297-302.|[4]Pia Bäckström, et al. Attenuation of Cocaine-Seeking Behaviour by the AMPA/kainate Receptor Antagonist CNQX in Rats. Psychopharmacology (Berl) . 2003 Feb;166 (1) :69-76.|[5]Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59 (1) :5-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor; Kainate Receptor
Citation 01
Acta Biomater. 2022 Oct 15:152:255-272.|Biomed Pharmacother. 2022 Jan:145:112446.|Cell Death Dis. 2022 Sep 12;13 (9) :786.|Cell Rep. 2025 May 14;44 (5) :115712.|Environ Sci Technol. 2023 Aug 22;57 (33) :12222-12233.|Front Cell Neurosci. 2019 Jun 25:13:276.|J Cell Mol Med. 2021 Aug;25 (15) :7342-7353.|J Integr Neurosci. 2022 Jun 28;21 (4) :121.|J Neurosci. 2024 Apr 10;44 (15) :e2062232024.|Nat Commun. 2024 May 15;15 (1) :4122.|Nat Neurosci. 2023 May;26 (5) :751-764.|PLoS Biol. 2025 Jan 27;23 (1) :e3003011.|SSRN. 2025 Jun 18.|Nat Commun. 2025 May 16;16 (1) :4560.

Alternative Products

CatalogName
MBS5752384CNQX
A16109-200CNQX 200mg
GTR19157920-01CNQX disodium
A16109-25CNQX 25mg

Popular Products