T-2 Toxin

T-2 Toxin

• CAS Number: 21259-20-1
• UNSPSC Description: T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains, LD50 values of T-2 Toxin in mice and rats are 5.2 and 1.5 mg/kg BWa,respectively [1]. T-2 Toxin (T-2 Mycotoxin) can be transformed into a variety of metabolite, the typical metabolites of T-2 toxin in animals are HT-2 toxin and T-2-triol, which are hydrolysates[1]. T-2 Toxin (T-2 Mycotoxin) is an inhibitor of protein synthesis resulting from binding peptidyltransferase, which is an integral part of the 60s ribosomal subunit. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides[1]. T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues[2].
• Target Antigen: Apoptosis; DNA/RNA Synthesis
• Type: Natural Products
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Purity: 99.23
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: C[C@@]12[C@@]3(OC3)[C@@](O[C@@]4([H])[C@@]2(C[C@H](OC(CC(C)C)=O)C(C)=C4)COC(C)=O)([H])[C@H](O)[C@H]1OC(C)=O
• Molecular Weight: 466.52
• References & Citations: [1]Li Y, et al. T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods. J Agric Food Chem. 2011 Apr 27;59(8):3441-53.|[2].Sun YX, et al. Toxicokinetics of T-2 toxin and its major metabolites in broiler chickens after intravenous and oral administration. J Vet Pharmacol Ther. 2015 Feb;38(1):80-5
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported