Cholera toxin
CAT:
804-HY-P1446-02
Size:
500 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Cholera toxin
- CAS Number: 9012-63-9
- UNSPSC Description: Cholera toxin (Choleragen), an AB(5)-subunit toxin, enters host cells by binding the ganglioside GM1 at the plasma membrane (PM) and travels retrograde through the trans-Golgi Network into the endoplasmic reticulum (ER)[1]. Choleragen activates adenylate cyclase by catalyzing ADP-ribosylation of Gs alpha, the stimulatory guanine nucleotide-binding protein[2].
- Target Antigen: Adenylate Cyclase
- Type: Reference compound
- Related Pathways: GPCR/G Protein
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Purity: 96.0
- Solubility: H2O : 10 mg/mL
- Smiles: [Cholera toxin]
- References & Citations: [1]Kellner A, et al. A binding motif for Hsp90 in the A chains of ADP-ribosylating toxins that move from the endoplasmic reticulum to the cytosol. Cell Microbiol. 2019;21(10):e13074.|[2]Tsai SC, et al. Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain. J Biol Chem. 1988;263(4):1768-1772.|[3]Wernick NL, et al. Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. Toxins (Basel). 2010;2(3):310-325.
- Shipping Conditions: Isolate blue ice and the product with bubble pack to avoid direct contact
- Storage Conditions: Store at 4°C, do not freeze
- Clinical Information: Launched